Recent approaches for enhancing the performance of dissolving microneedles in drug delivery applications

Dissolving microneedles (dMNs) are promising versatile drug delivery systems for the transdermal of numerous drugs, enabling their use in a wide range biomedical and pharmaceutical applications. Being made water-soluble polymers, dMNs own several advantages, including fast dissolution short application time which enhance patients’ compliance minimize damage to skin tissue. Moreover, they possess no biohazard risk as leave sharp waste behind. For these reasons, research on has increased dramatically recent years. The formulation successful requires well-defined pre-set design, considering goal payloads that will be used. Every aspect patch needles geometry, polymer composition, method formation payloads, direct effect mechanical properties MNs, affecting administration efficacy. Thus, there is need understand how each factor affects final optimize MN. Taking this into consideration, review serves guide dMN formulation, discussing different setbacks step possible strategies overcome them, improving administration, enhancing loading various molecules controlled release.